Decarboxylative aldol reactions of allyl β-keto esters via heterobimetallic catalysis

S Lou, JA Westbrook, SE Schaus

Index: Lou, Sha; Westbrook, John A.; Schaus, Scott E. Journal of the American Chemical Society, 2004 , vol. 126, # 37 p. 11440 - 11441

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Citation Number: 53

Abstract

Mild and selective heterobimetallic-catalyzed decarboxylative aldol reactions involving allyl β-keto esters have been developed. The reaction is promoted by Pd (0)-and Yb (III)-DIOP complexes at room temperature and involves the in situ formation of a ketone enolate from allyl β-keto esters followed by addition of the enolate to aldehydes. The reaction is a new example of heterobimetallic catalysis in which the optimized reaction conditions require ...