Il Farmaco

Synthesis and antibacterial activity of 1H-pyrazolo [3, 4-b] pyrazine and-pyridine derivatives

H Foks, D Pancechowska-Ksepko, A Kędzia, Z Zwolska…

Index: Foks, Henryk; Pancechowska-Ksepko, Danuta; Kedzia, Anna; Zwolska, Zofia; Janowiec, Mieczyslaw; Augustynowicz-Kopec, Ewa Farmaco, 2005 , vol. 60, # 6-7 p. 513 - 517

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Citation Number: 58

Abstract

The investigations of new pyrazine and pyridine derivatives showing an antibacterial activity have been made. Upon treatment of 3-chloro-2-cyanopyrazine [1] and 2-chloro-3- cyanopyridine with 1, 1-dimethyl-hydrazine, 1-aminopiperidine and 1-amino-4- methylpiperazine, either the pyrazolo-pyrazine (1), and-pyridine (2) derivatives, or ammonium salts (3–8) were obtained, according to the reaction conditions. Compound 1 ...