Piloty's acid derivative with improved nitroxyl-releasing characteristics

…, K Matsuo, K Kawai, N Ieda, T Suzuki, N Miyata

Index: Aizawa, Kazuyuki; Nakagawa, Hidehiko; Matsuo, Kazuya; Kawai, Kodai; Ieda, Naoya; Suzuki, Takayoshi; Miyata, Naoki Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2340 - 2343

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Citation Number: 11

Abstract

Recent studies have shown that nitroxyl (HNO)(1HNO/3NO−), which is the one-electron- reduced form of nitric oxide (NO), has unique biological activities, especially in the cardiovascular system, and HNO-releasing agents may have therapeutic potential. Since few HNO donors are available for use under physiological conditions, we synthesized and evaluated a series of Piloty's acid (PA) derivatives and evaluated their HNO-releasing ...