Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate

CE Mowbray, C Burt, R Corbau, S Gayton…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 20 p. 5857 - 5860

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Citation Number: 58

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The 3-cyanophenoxy group was identified as a ligand-lipophilicity efficient replacement for the 3,5-dichlorophenoxy substituent through an exploration of the SAR enabled by parallel chemistry using readily available phenols. ...