A stereoselective approach to the δ-lactone fragment of the lankacidin antibiotics

EJ Thomas, AC Williams

Index: Thomas, Eric J.; Williams, Andrew C. Journal of the Chemical Society, Chemical Communications, 1987 , # 13 p. 992 - 994

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Citation Number: 28

Abstract

An approach to the synthesis of the lactone fragment of the lankacidin antibiotics is described which is based upon stereoselective modification of an L-aspartic acid derived p-lactam. ... The lankacidins constitute a group of naturally occurring macrocyclic compounds which exhibit both antibiotic and antitumour activity, whilst being relatively non-toxic.1 Struc- turally they are characterized by a 17-membered carbocyclic ring, bridged by a 6-membered lactone as found in ...