Efficient and convenient entry to β-hydroxy-β-trifluoromethyl-β-substituted ketones and 2, 6-disubstituted 4-trifluoromethylpyridines based on the reaction of …

…, Y Yamaguchi, W Hashimoto, K Matsunaga…

Index: Funabiki; Isomura; Yamaguchi; Hashimoto; Matsunaga; Shibata; Matsui Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 20 p. 2578 - 2582

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Citation Number: 22

Abstract

Recently, we have demonstrated that enamine- or imine-assisted facile generation of trifluoroacetaldehyde from trifluoroacetaldehyde ethyl hemiacetal or hydrate and sequential carbon–carbon bond formation lead to β-hydroxy-β-trifluoromethyl ketone derivatives in the absence of additives. 6 In this paper we describe the reaction of trifluoromethyl ketones with various enamines or imines followed by hydrolysis affording β-hydroxy-β-trifluoromethyl-β-substituted ketones in good yields ...