Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
RC Oslund, N Cermak, MH Gelb
Index: Oslund, Rob C.; Cermak, Nathan; Gelb, Michael H. Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4708 - 4714
Full Text: HTML
Citation Number: 95
Abstract
We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6, 7-benzoindoles, and indolizines derived from LY315920, a well- known indole-based sPLA2 inhibitor. Using the human group X sPLA2 crystal structure, we prepared a highly potent and selective indole-based inhibitor of this enzyme. Also, we report human and mouse group IIA and IIE specific inhibitors and a substituted 6, 7-benzoindole ...
Related Articles:
Carbocyclic [g] indole inhibitors of human nonpancreatic s-PLA2
[Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G. Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896]
Carbocyclic [g] indole inhibitors of human nonpancreatic s-PLA2
[Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G. Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896]
[Woodcock; Davies Journal of the Chemical Society, 1958 , p. 4723,4726]
[Narasimhan,N.S.; Mali,R.S. Tetrahedron, 1975 , vol. 31, p. 1005 - 1009]
New Efficient Route to Fused Aryltetrahydroindolizinones via N??Acyliminium Intermediates
[Chiurato, Matteo; Routier, Sylvain; Troin, Yves; Guillaumet, Gerald European Journal of Organic Chemistry, 2009 , # 18 p. 3011 - 3021]