Rat liver microsomal cytochrome P450-dependent oxidation of 3, 5-disubstituted analogues of paracetamol
…, LLP Van Stee, JNM Commandeur, NPE Vermeulen
Index: Bessems; Te Koppele; Van Dijk; Van Stee; Commandeur; Vermeulen Xenobiotica, 1996 , vol. 26, # 6 p. 647 - 666
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Citation Number: 14
Abstract
1. The cytochrome P450-dependent binding of paracetamol and a series of 3, 5- disubstituted paracetamol analogues (R=-F,-Cl,-Br,-I,-CH3,-C2H5,-i C3H7) have been determined with β-naphthoflavone (βNF)-induced rat liver microsomes and produced reverse type I spectral changes. K s, app varied from 0· 14 mM for 3, 5-di i C3H7- paracetamol to 2· 8 mM for paracetamol. 2. All seven analogues underwent rat liver ...
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