A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones using microwave heating
S Kamila, H Ankati, E Harry, ER Biehl
Index: Kamila, Sukanta; Ankati, Haribabu; Harry, Emily; Biehl, Edward R. Tetrahedron Letters, 2012 , vol. 53, # 17 p. 2195 - 2198
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Citation Number: 11
Abstract
(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (7a–w) have been synthesized by the Knoevenagel condensation reaction of 3-(aryl/alkyl-2- ylmethyl)-2-thioxothiazolidin-4-ones (3a–d) with suitably substituted 2-(1H-indol-3-yl) 2- oxoacetaldehydes (6a–g) under microwave conditions. The thioxothiazolidin-4-ones were prepared from the corresponding aryl/alkyl amines (1a–d) and di-(carboxymethyl)- ...
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