Application of Rh-catalyzed cyclization to the formation of a chiral quaternary carbon.

M Takahashi, M Tanaka, E Sakamoto, M Imai…

Index: Takahashi; Tanaka; Sakamoto; Imai; Funakoshi; Sakai; Suemune Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 11 p. 1822 - 1825

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Citation Number: 6

Abstract

Rh-Catalyzed cyclization was applied to the formation of a chiral quaternary carbon. It has become clear that the Rh-complex can discriminate between isopropenyl and 2-isopentenyl (or isopentyl) substituents, and the cyclization afforded 3, 3, 4-trisubstituted cyclopentanones with a chiral quaternary carbon in a stereoselective manner. The cyclization of 4-pentenals 6a, b by an achiral neutral Rh (PPh 3) 3 Cl afforded 3, 3, 4-cis-trisubstituted ...