Organic & biomolecular chemistry

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

J Chen, L Zhou, YY Yeung

Index: Chen, Jie; Zhou, Ling; Yeung, Ying-Yeung Organic and Biomolecular Chemistry, 2012 , vol. 10, # 19 p. 3808 - 3811

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Citation Number: 52

Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1, 2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2- substituted pyrrolidine.