Metabolically labile cannabinoid esters: a 'soft drug'approach for the development of cannabinoid-based therapeutic drugs
…, S Bertini, M Digiacomo, M Bifulco, V Di Marzo…
Index: Minutolo; Cascio; Carboni; Bisogno; Prota; Bertini; Digiacomo; Bifulco; Di Marzo; Macchia Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4878 - 4881
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Citation Number: 8
Abstract
Biphenylic ester derivatives, designed by using a 'soft-drug'approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.
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