An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity
S Gil, M Parra, P Rodríguez
Index: Gil, Salvador; Parra, Margarita; Rodriguez, Pablo Molecules, 2008 , vol. 13, # 4 p. 716 - 728
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Citation Number: 4
Abstract
Abstract: Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields, to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. This two step methodology improves upon previously described results. Poor ee's resulted from our attempts to drive the enantioselectivity of this transformation by chiral amide induction.
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