Journal of the American Chemical Society

Total synthesis of (+)-leinamycin

Y Kanda, T Fukuyama

Index: Kanda; Fukuyama Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8451 - 8452

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Citation Number: 122

Abstract

Leinamycin (1) has recently been isolated from a culture broth of Streptomyces sp. at Kyowa Hakko and has been shown to exhibit potent antitumor activities against experimental tumors. The relative configuration of leinamycin was determined by an X-ray crystallographic analy~ is,~ and the absolute stereochemistry was deduced as shown on the basis of the degradation studies4 The unique structural features of leinamycin include the l-oxo-1, 2- ...