Chemical delivery system of metaiodobenzylguanidine (MIBG) to the central nervous system

…, J Henry, V Levacher, C Perrio, L Barré

Index: Gourand, Fabienne; Mercey, Guillaume; Ibazizene, Meziane; Tirel, Olivier; Henry, Joel; Levacher, Vincent; Perrio, Cecile; Barre, Louisa Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1281 - 1287

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Citation Number: 14

Abstract

The aim of the present investigation was to apply a chemical delivery system (CDS) to MIBG (4) with the purpose of delivering this drug to the CNS. Compound 4 has been linked to a 1, 4-dihydroquinoline moiety in order to achieve its CNS penetration, and here we report the synthesis to link 4 to the chemical delivery system and the radiosynthesis with carbon-11 of the “CDS-4 entity”. After iv injection into rats of the [11C] CDS-4, the follow-up study of the ...