Reaction of Carbon Disulfide with Active Methylenes: Novel Synthesis of Thiophene, Thieno [2, 3-b] thiophene, Thieno [3, 2-c] pyrazole and Thieno [3, 2-b] pyridine …

…, A Habashi, NI Abdel-Sayed, SS Osman

Index: Mohareb, Rafat M.; Sherif, Sherif M.; Habashi, Adiba; Abdel-Sayed, Nadia I.; Osman, Samia S. Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 9 p. 1578 - 1586

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Citation Number: 14

Abstract

Abstract The active methylene compounds-derivatives of malonic or 4-oxobutanoic acid- reacted with carbon disulfide in dimethyl formamide containing potassium hydroxide to yield the non-isolable dipotassium disulfide intermediates. The latter were cyclized by α- haloketones to give thiophene, thieno [2, 3-b] thiophene, thieno [3, 2-c] pyrazole and thieno [3, 2-b] pyridine derivatives. The reactivity of the products toward various reagents was ...