Synthesis and biological evaluation of new sulfonamide derivatives as potential anti-Trypanosoma cruzi agents

…, M Edith Lemus-Hernandez…

Index: Bocanegra-Garcia, Virgilio; Villalobos-Rocha, Juan Carlos; Nogueda-Torres, Benjamin; Lemus-Hernandez, Maria Edith; Camargo-Ordonez, Argelia; Rosas-Garcia, Ninfa Maria; Rivera, Gildardo Medicinal Chemistry, 2012 , vol. 8, # 6 p. 1039 - 1044

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Citation Number: 3

Abstract

Chagas disease continues to be one of the main parasitic diseases in Latin America. Despite the fact that it was discovered more than 100 years ago, no suitable pharmacologic treatment is available. We report the synthesis of new sulfonamidoquinoline and sulfonamides derivatives that were evaluated in vitro against two strains of Trypanosoma cruzi (NINOA and INC-5). Structure-activity relationship analysis indicated that small ...