The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

JM Matthews, N Qin, RW Colburn, SL Dax…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2922 - 2926

Full Text: HTML

Citation Number: 18

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Investigation of alternate scaffolds related to compound 2, using chemistry outlined in Scheme 1, resulted in the synthesis of compounds 4, 19 and 20 as shown in Table 1. Though several of the compounds had similar potency to ...