New prodrugs of Adefovir and Cidofovir

…, A Holý, J Balzarini, R Snoeck, M Krečmerová

Index: Tichy, Tomas; Andrei, Graciela; Dracinsky, Martin; Holy, Antonin; Balzarini, Jan; Snoeck, Robert; Krecmerova, Marcela Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 11 p. 3527 - 3539

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Citation Number: 20

Abstract

Abstract New Adefovir (PMEA) prodrugs with a pro-moiety consisting of decyl or decyloxyethyl chain bearing hydroxyl function (s), hexaethyleneglycol or a (5-methyl-2-oxo- 1, 3-dioxolen-4-yl) methyl unit were prepared starting from the tetrabutylammonium salt of the phosphonate drug and an appropriate alkyl bromide or tosylate. Analogously, two esters of Cidofovir [(S)-HPMPC] bearing a hexaethyleneglycol moiety were prepared. The activity ...