The Journal of organic chemistry

Nitroarylstannanes as Synthons for the Preparation of Phenanthridine and Benzo [i] phenanthridine Derivatives

D Li, B Zhao, EJ LaVoie

Index: Li, Dajie; Zhao, Baoping; LaVoie, Edmond J. Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2802 - 2805

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Citation Number: 45

Abstract

Substituted benzo [c] phenanthridine alkaloids and, more recently, benzacridine derivatives have demonstrated activity as topoisomerase I poisons and were shown to possess antitumor activity. 1, 2 In view of our interest in furthering the structure activity associated with these antitumor compounds, we explored synthetic methods to provide for variously substituted phenanthridine and benzo [i] phenanthridines. Preparation of the N-oxide of ...

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