Staudinger ligation towards cyclodextrin dimers in aqueous/organic media. Synthesis, conformations and guest-encapsulation ability

…, IM Mavridis, K Yannakopoulou

Index: Manouilidou, Malamatenia D.; Lazarou, Yannis G.; Mavridis, Irene M.; Yannakopoulou, Konstantina Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 774 - 783

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Citation Number: 2

Abstract

Abstract β-Cyclodextrin (β-CD) dimers have been prepared using the bioorthogonal Staudinger ligation for the first time. In addition to a known linker, methyl 2- (diphenylphosphanyl) terephthalate, a doubly active linker was specifically developed that enabled connection of two β-CD units in a single step and in aqueous/organic media, under mild conditions and with good yields. A three-carbon spacer between the β-CD torus and ...