Tetrahedron letters

A general method for the preparation of 3-acyl-4-cyano-5-amino-pyrazoles

M Ge, E Cline, L Yang

Index: Ge, Min; Cline, Eric; Yang, Lihu Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5797 - 5799

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Citation Number: 27

Abstract

Recently we were interested in a series of 3-acyl-4-cyano-5-amino-pyrazoles. This type of pyrazoles is usually synthesized using the diazonium salt of aniline (Fig. 1, routes a and b). 3 Obviously, the success of both methods depends on the stability and reactivity of the diazonium salts. Because the diazonium salts of alkyl amines are often unstable, the N-1 substituents of the pyrazoles are limited to phenyl groups. For broader N-1 substituent changes, a ...