Scale-up of the synthesis of a pyrimidine derivative directly on solid support
M Meisenbach, T Allmendinger…
Index: Meisenbach, Mark; Allmendinger, Thomas; Mak, Ching-Pong Organic Process Research and Development, 2003 , vol. 7, # 4 p. 553 - 558
Full Text: HTML
Citation Number: 15
Abstract
The solid-phase synthesis of 4-(2-amino-6-phenylpyrimidin-4-yl) benzamide, a compound obtained through combinatorial chemistry and parallel synthesis, can be scaled up directly on solid support in excellent yields and high purity. By applying highly loaded aminomethyl polystyrene as solid support, a good ratio between the product and the starting resin is achieved. For comparison, the synthesis was also performed in solution. The solid-phase ...
Related Articles:
RhI??Catalyzed Hydration of Organonitriles under Ambient Conditions
[Goto, Akihiro; Endo, Kohei; Saito, Susumu Angewandte Chemie - International Edition, 2008 , vol. 47, # 19 p. 3607 - 3609]
[Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Gogsig, Thomas M.; Skrydstrup, Troels Organic Letters, 2011 , vol. 13, # 16 p. 4454 - 4457]
[Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias Chemistry - A European Journal, 2012 , vol. 18, # 2 p. 419 - 422]