SYNTHESIS OF CHIRAL THIOCARBAMOYLPHOSPHINES DERIVED FROM AMINO ACIDS1

U Kunze, R Burghardt

Index: Kunze, U.; Burghardt, R. Phosphorus and Sulfur and the Related Elements, 1987 , vol. 29, p. 373 - 376

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Citation Number: 2

Abstract

Abstract The methylester hydrochlorides of the (S)-amino acids L-alanine (la), L- phenylalanine (1b), L-valine (1c) and L-lysine (1d) were converted to the corresponding isothiocyanates 2a-d by thiophosgenation. 2a-d react with secondary phosphines and phosphine oxides to give the thiocarbamoylphosphines 3a-d and P-oxides 4a, b.