Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists

N Takahashi, K Maeda, Y Asano…

Index: Takahashi, Naoki; Maeda, Koji; Asano, Yukiyasu; Watanabe, Nobuhide Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 488 - 498

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Citation Number: 5

Abstract

Abstract A series of 1-benzylindole-based TRβ agonists were prepared and evaluated. Compounds 11b′ and 11c′ were found to have cholesterol-lowering in a rat model with marginal effects on cardiac function and HPT axis. The present work illustrates the potential use of indoles as inner ring isosteres.