Iodine/palladium approaches to the synthesis of polyheterocyclic compounds
S Mehta, RC Larock
Index: Mancuso, Raffaella; Mehta, Saurabh; Gabriele, Bartolo; Salerno, Giuseppe; Jenks, William S.; Larock, Richard C. Journal of Organic Chemistry, 2010 , vol. 75, # 3 p. 897 - 901
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Citation Number: 92
Abstract
A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I2 or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently incorporated under mild reaction conditions. In addition, variations of this strategy afford a variety of ...
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