Bulletin of the Chemical Society of Japan

Design and Synthesis of Macromonocyclic Polyamines Composed of Natural Methylene Arrays

M Iwata, H Kuzuhara

Index: Iwata, Masaaki; Kuzuhara, Hiroyoshi Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 198 - 210

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Citation Number: 19

Abstract

A general synthetic method applicable to acyclic and cyclic polyamines was developed. The methodology was exemplified by systematical synthesis of twelve macromonocyclic polyamines, 1 ([17] N 4) through 12 ([35] N 8), composed of the combination of four natural polyamine segments, spermidine, spermine, thermine, and thermospermine. These twelve designed macrocycles are exhausted numbers of possible structures defined by three ...