Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide

S Terracciano, I Bruno, E D'Amico, G Bifulco…

Index: Terracciano, Stefania; Bruno, Ines; D'Amico, Elisabetta; Bifulco, Giuseppe; Zampella, Angela; Sepe, Valentina; Smith, Charles D.; Riccio, Raffaele Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 13 p. 6580 - 6588

Full Text: HTML

Citation Number: 26

Abstract

In the recent years, we focused our attention on the cyclodepsipeptide Jaspamide 1, an interesting marine metabolite, possessing a potent inhibitory activity against breast and prostate cancer, as a consequence of its ability to disrupt actin cytoskeleton dynamics. Although its biological profile has been well determined, many mechanistic details are still missing in terms of molecular target identification. For this reason, we decided to ...