Regioselective copper-catalyzed CN and CS bond formation using amines, thiols and halobenzoic acids
S Liu, JPC Pestano, C Wolf
Index: Liu, Shuanglong; Pestano, John Paul C.; Wolf, Christian Synthesis, 2007 , # 22 p. 3519 - 3527
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Citation Number: 18
Abstract
Abstract A regioselective method for highly efficient CN and CS bond formation with 2- halobenzoic acids is described. The Cu/Cu 2 O-catalyzed reaction is carried out in 2- ethoxyethanol or ethylene glycol diethyl ether and does not require the use of strong base or other additives. This procedure eliminates the need for acid protection, tolerates a wide range of functional groups and provides aromatic and aliphatic amines and sulfides in 81- ...
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