Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents

S Xu, S Li, Y Tang, J Zhang, S Wang, C Zhou…

Index: Xu, Shengjie; Li, Shenghui; Tang, Yonghe; Zhang, Jinchao; Wang, Shuxiang; Zhou, Chuanqi; Li, Xiaoliu Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5610 - 5616

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Citation Number: 7

Abstract

Abstract A novel series of N-arylpyrazole derivatives (5a–5d, 7a–7c) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4- fluoronitrobenzene in the presence of base. The structures of these compounds were established on the basis of elemental (C, H, and N) and spectral analysis (1 H NMR, 13 C NMR, HRMS, and FT-IR). All the compounds were tested for their cytotoxic activity in vitro ...