Synthesis and antileishmanial activity of lipidic amino alcohols

…, AC De Almeida, EFC Reis, AD Da Silva

Index: Coimbra, Elaine S.; De Almeida, Mauro V.; Junior, Celso O. R.; Taveira, Aline F.; Da Costa, Cristiane F.; De Almeida, Ana C.; Reis, Elaine F. C.; Da Silva, Adilson D. Chemical Biology and Drug Design, 2010 , vol. 75, # 2 p. 233 - 235

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Citation Number: 18

Abstract

In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 lM. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms. Key words: amino alcohols, ...