In??vitro transdermal penetration of cytarabine and its N4??alkylamide derivatives

LJ Legoabe, JC Breytenbach, DD N'Da…

Index: Legoabe, Lesetja J.; Breytenbach, Jaco C.; N'Da, David D.; Breytenbach, J. Wilma Journal of Pharmacy and Pharmacology, 2010 , vol. 62, # 6 p. 756 - 761

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Citation Number: 4

Abstract

Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties. Methods The alkylamide derivatives of cytarabine were synthesised by acylation at the N4-amino group by the mixed anhydride method. The in-vitro permeation studies were performed using the Franz diffusion cell methodology. ...