New C (4)??Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution

…, V Niggli, M Wartmann, JL Reymond

Index: Bensel, Nicolas; Lagnoux, David; Niggli, Verena; Wartmann, Markus; Reymond, Jean-Louis Helvetica Chimica Acta, 2004 , vol. 87, # 9 p. 2266 - 2272

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Citation Number: 7

Abstract

Abstract Electrophilic alkylation of colchicine at C (4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H 2 SO 4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards various tumor cell lines, and their stimulatory effect on the development of polarity in human neutrophils.