Development of a novel class of B-Raf v600e-selective inhibitors through virtual screening and hierarchical hit optimization

X Kong, J Qin, Z Li, A Vultur, L Tong, E Feng…

Index: Organic and Biomolecular Chemistry, , vol. 10, # 36 p. 7402 - 7417

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Citation Number: 10

Abstract

... Subsequent scaffold-based analogue searching and medicinal chemistry efforts significantly improved both the ... SBVS) has become a powerful tool in the medicinal chemists' toolkit, and ... Fig. 2 Chemical structures of the query templates employed in SHAFTS searching and hit ...