Synthesis of 10??Methylacridin??9 (10H)??ones through Cu??Catalyzed Intramolecular Oxidative C (sp2)–H Amination of 2??(Methylamino) benzophenones

J Huang, C Wan, MF Xu, Q Zhu

Index: Huang, Jinbo; Wan, Congqing; Xu, Ming-Fang; Zhu, Qiang European Journal of Organic Chemistry, 2013 , # 10 p. 1876 - 1880

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Citation Number: 4

Abstract

Abstract An efficient synthesis of a diverse set of 10-methylacridin-9 (10H)-ones from 2- (methylamino) benzophenones has been developed. The reaction proceeds though Cu- catalyzed intramolecular aromatic C–H amination by using O 2 as the sole oxidant to provide the desired products in moderate to good yields. In addition, 2-allylamino-and 2- (benzylamino) benzophenones as well as unprotected substrates can also undergo the C ...