Tetrahedron letters

Cerium (IV) ammonium nitrate (CAN) catalyzed aza-Michael addition of amines to α, β-unsaturated electrophiles

Z Duan, X Xuan, T Li, C Yang, Y Wu

Index: Duan, Zheng; Xuan, Xuejie; Li, Ting; Yang, Chenfei; Wu, Yangjie Tetrahedron Letters, 2006 , vol. 47, # 31 p. 5433 - 5436

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Citation Number: 69

Abstract

The development of catalysts for the formation of carbon–nitrogen bonds by simple addition of amines to double bonds is a focus of increasing interest. 1 The aza-Michael reaction provides an easy and direct route to β-amino esters. 2 In general, this type of conjugated addition reaction of nucleophiles to unsaturated carbonyl compounds requires basic conditions or acidic catalysts. 3 In order to overcome some of these limitations, a number of alternative ...