Potentiation of mitochondrial Ca 2+ sequestration by taurine

M Palmi, GT Youmbi, F Fusi, GP Sgaragli…

Index: Palmi, Mitri; Youmbi, Gisele Tchuisseu; Fusi, Fabio; Sgaragli, Gian P.; Dixon, Henry B.F.; Frosini, Maria; Tipton, Keith F. Biochemical Pharmacology, 1999 , vol. 58, # 7 p. 1123 - 1131

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Citation Number: 76

Abstract

The effects of taurine (2-aminoethanesulphonic acid) and its analogues, 2- aminoethylarsonic acid, 2-hydroxyethanesulphonic (isethionic) acid, 3- aminopropanesulphonic acid, 2-aminoethylphosphonic acid, and N, N-dimethyltaurine, were studied on the transport of Ca2+ by mitochondria isolated from rat liver. Taurine enhanced Ca2+ uptake in an apparently saturable process, with a Km value of about 2.63 ...