Bioconjugate chemistry

N-glycan targeted gene delivery to the dendritic cell SIGN receptor

K Anderson, C Fernandez, KG Rice

Index: Baumhover, Nicholas J.; Anderson, Kevin; Fernandez, Christian A.; Rice, Kevin G. Bioconjugate Chemistry, 2010 , vol. 21, # 1 p. 74 - 83

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Citation Number: 18

Abstract

A novel nonviral gene delivery vector composed of a high-mannose N-glycan conjugated to a polyacridine peptide was prepared. The glycopeptide was designed to bind to plasmid DNA by a combination of polyintercalation and ionic binding, and to the DC-SIGN (dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin) receptor expressed on CHO cells by recognition of the high-mannose N-glycan. The glycopeptide conjugate was ...