Synthesis of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol

F Fernández, X García-Mera, M Morales, L Vilariño…

Index: Fernandez, Franco; Garcia-Mera, Xerardo; Morales, Melvin; Vilarino, Leonardo; Caamano, Olga; De Clercq, Eric Tetrahedron, 2004 , vol. 60, # 41 p. 9245 - 9253

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Citation Number: 18

Abstract

A series of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol were synthesized from (±)-cis-3-hydroxymethyl-1-indanol, an appropriately functionalized derivative of which was reacted with 6-chloropurine in the presence of NaH and 18-crown-6 ether to prepare a key intermediate that gave access to the target molecules, purinylcarbanucleosides in which position 6 is occupied by a chloro, hydroxy, methoxy, ...