Advanced Synthesis & Catalysis

(R/S)??BINOL?螃窿?Phosphoryloxy Enecarbamate??Mediated and (R/S)??Titanium (IV) BINOLates??Catalyzed Enantioselective Intramolecular Heck/Aza??Diels–Alder …

IA Khan, AK Saxena

Index: Khan, Imran A.; Saxena, Anil K. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2617 - 2626

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Citation Number: 3

Abstract

Abstract: An (R/S)-titanium (IV) BINOLate-catalyzed highly enantioselective intramolecular Heck/aza-Diels–Alder cycloaddition (IHADA) cascade was developed to prepare tetrahydropyridoindoles (tHPs) and octahydropyrazinopyridoindoles (oHPPs) from in situ generated (R/S)-BINOL α-phosphoryl-ACHTUNGTRENNUNGoxy carbamate (αPPC2) in one pot. Chiral cooperativity between (R/S)-αPPC2 and (R/S)-titanium (IV)