Mutual prodrugs of 4-biphenylacetic acid and phytophenolics as safer NSAIDs: synthetic and spectral studies
P Sharma, G Kaur, S Kansal, SK Chandiran
Index: Sharma, Pritam Dev; Kaur, Gurbinder; Kansal, Sumeet; Chandiran, Senthil Kumar Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 10 p. 2159 - 2164
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Citation Number: 11
Abstract
Abstract: 4-Biphenylacetic acid (4-BPA), the active metabolite of NSAID fenbufen has been modified using mutual prodrug approach. Number of 4-BPA derivatives have been synthesised as potential mutual prodrugs by the attachment of several phytophenols/alcohol as promoieties through ester linkage, directly as well as through spacers, with the objective of obtaining safer NSAIDs devoid of their ulcerogenic side effects. The structures of these ...