Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring

…, P Koos, A Metzger, P Knochel, SV Ley

Index: Brodmann, Tobias; Koos, Peter; Metzger, Albrecht; Knochel, Paul; Ley, Steven V. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 1102 - 1113

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Citation Number: 48

Abstract

A newly developed microscale ReactIR flow cell was used as a convenient and versatile inline analytical tool for Grignard formation in continuous flow chemical processing. The LiCl- mediated halogen/Mg exchange reaction was used for the preparation of functionalized arylmagnesium compounds from aryl iodides or bromides. Furthermore, inline IR monitoring was used for the analysis of conversion and possible byproduct formation, as well as a ...