Enantioselective Synthesis of Tunable Chiral Clickphine P, N-Ligands and Their Application in Ir-Catalyzed Asymmetric Hydrogenation

J Wassenaar, RJ Detz, SY de Boer, M Lutz…

Index: Lutz et al. Journal of the American Chemical Society, 1948 , vol. 70, p. 2015,2022

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Citation Number: 2

Abstract

A small library of highly tunable chiral Clickphine P, N-ligands has been prepared in an enantioselective fashion by CuI-catalyzed asymmetric propargylic amination using a single chiral complex and a subsequent in situ cycloaddition click reaction. The scope of the propargylic amination to yield optically active triazolyl amines is described. The amines are transformed in a one-pot procedure to the corresponding Ir–Clickphine complexes, which ...