Regioselective synthesis of 1, 3, 5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor

YR Huang, JA Katzenellenbogen

Index: Organic letters, , vol. 2, # 18 p. 2833 - 2836

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Citation Number: 195

Abstract

... Volume: Page: ... Organic Letters. ... Initially, we used MnO 2 , either at high temperature (reflux benzene) or with ultrasonic agitation, and we obtained the desired 1,3,5-triaryl-4-alkylpyrazoles 9 in 66% yield, but the reaction took 48 h. Later, DDQ was found to be a ...