Synlett

Novel Method for the Synthesis of α-Amino-α′-hydroxyalkylphosphinic Acids and Bis (α-aminoalkyl) phosphinic Acids: Nuclephilic Addition of α-Hydroxy-H- …

B Kaboudin, H Haghighat, S Alaie, T Yokomatsu

Index: Kaboudin, Babak; Haghighat, Hamideh; Alaie, Saied; Yokomatsu, Tsutomu Synlett, 2012 , vol. 23, # 13 p. 1965 - 1969

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Citation Number: 5

Abstract

Abstract We report here a novel and simple method for the synthesis of α-amino-α′- hydroxyalkylphosphinic acids in good yields in two simple steps without any protection– deprotection steps. We have developed an efficient method for the synthesis of α-amino-α′- hydroxyalkylphosphinic acids via the reaction of easily available α-hydroxyalkylphosphinic acids with diimines. Treatment of α-hydroxyalkylphosphinic acids with diimines in the ...