Synthesis of new 1??[4??methane (amino) sulfonylphenyl)]??5??[4??(aminophenyl)]??3??trifluoromethyl??1H??pyrazoles
KRA Abdellatif, MA Chowdhury…
Index: Abdellatif, Khaled R. A.; Chowdhury, Morshed A.; Knaus, Edward E. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 6 p. 1707 - 1710
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Citation Number: 9
Abstract
The original concept that an anti-inflammatory drug which selectively inhibits the inducible cyclooxygenase-2 (COX-2) isozyme in the periphery would be devoid of adverse ulcerogenic effects was confirmed with the development of celecoxib [1], rofecoxib [2] and valdecoxib [3]. It soon became evident that highly selective COX-2 inhibitors alter the balance in the COX pathway causing a decrease in the level of the favorable vasodilatory ...
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