Design, synthesis and structure–activity relationship of novel quinoxaline derivatives as cancer chemopreventive agent by inhibition of tyrosine kinase receptor

SA Galal, AS Abdelsamie, SM Soliman, J Mortier…

Index: Galal, Shadia A.; Abdelsamie, Ahmed S.; Soliman, Salwa M.; Mortier, Jeremie; Wolber, Gerhard; Ali, Mamdouh M.; Tokuda, Harukuni; Suzuki, Nobutaka; Lida, Akira; Ramadan, Raghda A.; El Diwani, Hoda I. European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 115 - 124

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Citation Number: 15

Abstract

Abstract The cancer chemopreventive activity of quinoxaline derivatives 1–20 has been evaluated by studying the inhibitory effect on Epstein–Barr virus early antigen (EBV-EA) activation. The quinoxaline derivatives 1–20 showed inhibitory effect on EBV-EA activation without cytotoxicity on Raji cells. All compounds exhibited dose dependent inhibitory activities, most of them showed significant activity at 1000 mol ratio/12-O- ...