Heteroaromatic synthesis via olefin cross-metathesis: entry to polysubstituted pyridines
TJ Donohoe, JA Basutto, JF Bower, A Rathi
Index: Donohoe, Timothy J.; Basutto, Jose A.; Bower, John F.; Rathi, Akshat Organic Letters, 2011 , vol. 13, # 5 p. 1036 - 1039
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Citation Number: 46
Abstract
The olefin cross-metathesis reaction provides a rapid and efficient method for the synthesis of α, β-unsaturated 1, 5-dicarbonyl derivatives which then serve as effective precursors to mono− tetrasubstituted pyridines. Manipulation of the key 1, 5-dicarbonyl intermediate allows access to pyridines with a wide range of substitution patterns. An extension of this methodology facilitates the preparation of pyridines embedded within macrocycles, as ...
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