Tetrahedron Letters

Sulfated titania catalyzed water mediated efficient synthesis of dicoumarols—a green approach

B Karmakar, A Nayak, J Banerji

Index: Karmakar, Bikash; Nayak, Anupam; Banerji, Julie Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4343 - 4346

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Citation Number: 35

Abstract

An efficient, mild, and environmental friendly method has been developed for the synthesis of dicoumarols in water over Lewis and Bronsted acid catalyst sulfated titania (TiO2/SO42−). The method involves the condensation of various aromatic and aliphatic aldehydes with 4- hydroxycoumarin. It affords the corresponding product in high yield with short reaction times employing a very low loading of catalyst. The catalyst was reused several times without ...