Nickel-catalyzed reductive coupling of alkynes and epoxides

C Molinaro, TF Jamison

Index: Molinaro, Carmela; Jamison, Timothy F. Journal of the American Chemical Society, 2003 , vol. 125, # 27 p. 8076 - 8077

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Citation Number: 107

Abstract

Nickel-catalyzed, intramolecular and intermolecular reductive coupling of alkynes and epoxides affords synthetically useful homoallylic alcohols of defined alkene geometry. Very high regioselectivity is generally observed, and cyclizations proceed with complete selectivity for endo epoxide opening. This catalytic reaction represents the first use of a non- π-based electrophile in a growing class of nickel-catalyzed, multicomponent coupling ...